CDC for Removal of toxins from Biofluids

Overview

High levels of proinflammatory cytokines are associated with high fatality in infectious conditions such as sepsis, liver toxicity, and ebola, which is typically brought about by rapidly escalating levels of cytokines. There is a need for materials and techniques capable of quickly removing cytokines from blood to prevent this “cytokine storm”.

Researchers at Drexel University have discovered that a family of open surface graphitic materials, including exfoliated graphite, graphene aerogels, graphene platelets, and other graphenic materials are excellent and selective adsorbents of proteins, including cytokines. In place of traditional pores, characteristic of activated carbons and other materials used for blood cleansing, this family of adsorbents offer open hydrophobic surfaces which are fully available to hydrophobic domains on targeted proteins, while small hydrophilic materials do not adhere.

Applications

  • Cytokine removal for liver toxicity
  • Cytokine removal for sepsis
  • Cytokine removal for ebola virus disease

Advantages

  • Selective removal of target proteins
  • Cheaper than antibodies or pharmaceutical agents

  •        Fast removal kinetics may eliminate need for blood thinning agents (i.e. heparin)

Intellectual Property and Development Status

United States Issued Patent- 8,137,560

Commercialization Opportunities

 

Contact Information

Web Site

">Drexel Nanomaterials Group

 

For Intellectual Property and Licensing Information:

 

Elizabeth Poppert, Ph.D.

Licensing Manager

Office of Technology Commercialization

The Left Bank

3180 Chestnut Street, Suite 104

Philadelphia, PA 19104

Phone: 1-215-895-0999

Email: lizpoppert@drexel.edu

 

For Technical Information:

Yury Gogotsi, Ph.D., D.Sc.

Distinguished University Professor and Trustee Chair

Director, A.J. Drexel Nanomaterials Institute

Department of Materials Science and Engineering

3141 Chestnut St.

Philadelphia, PA 19104, USA

Phone: 1-215-895-6446

E-mail: gogotsi@drexel.edu