Telomere assay for the detection of alternative lengthening of telomere (ALT) activity in cells
Overview
Executive Statement:
A unique tool for distinguishing cancer cells based on telomere maintenance mechanisms, providing potential biomarkers for cancer subtypes and therapeutic responses.
Description:
This technology provides detailed telomere profiling from individual chromosomes, capable of differentiating Alternative Lengthening of Telomere (ALT+) cancer cells from telomerase (TEL+) cancer cells. This technology identifies unique telomeric profiles and has implications in discerning subtypes of ALT+ cancer and monitoring responses to treatments. This use case can be extended to other disease and cancer type diagnosis and monitoring for cell and gene therapy.
Market Applications
- Application in cancer research for understanding different types of cancers
- Useful tool for personalized medicine in cancer treatment
- Monitoring the effectiveness of cancer treatments in real-time
Key Advantages
- Allows measurement and analysis of telomere lengths from individual chromosomes
- Capable of distinguishing between ALT+ and TEL+ cancer cells
- Identifies unique telomeric profiles in ALT+ cancer cells
- Can potentially aid in identifying subtypes of ALT+ cancer
- Useful in monitoring responses to cancer treatments
Problems Solved
- Lack of tools to differentiate between ALT+ and TEL+ cancer cells based on telomere profiles
- Difficulty in monitoring responses to cancer treatments at the genomic level
Intellectual Property and Development Status
United States Provisional filed.
References
Genes 2023: Single-Molecule Telomere Assay via Optical Mapping (SMTA-OM) Can Potentially Define the ALT Positivity of Cancer
Commercialization Opportunities